A microbial metabolite that reflects gut health

Among the many metabolites produced by the gut microbiota, indole-3-propionic acid (IPA) stands out for its wide-ranging health relevance. Made exclusively by certain gut bacteria from dietary tryptophan, IPA represents one of the clearest examples of how the microbiome can influence human physiology – not just locally in the gut, but throughout the body.

Scientific research has linked higher levels of IPA with a variety of health-supporting effects. These include strengthening the gut lining, supporting balanced immune responses, aiding blood sugar regulation, and even influencing brain and liver function. While the mechanisms are complex, what’s clear is this: IPA reflects a pattern of microbial activity that supports long-term metabolic and immune balance.

What makes IPA meaningful to track?

Gut health & barrier function: IPA helps maintain the integrity of the intestinal lining, limiting the passage of unwanted bacterial components (like LPS) into the bloodstream and helping to reduce signals of immune stress.
Immune activation: Studies have shown that people with higher IPA levels tend to have lower indicators of persistent immune stress and activation.
Metabolic balance: Higher IPA levels have been associated with favorable blood sugar balance and support for overall energy metabolism.
Neuroprotection & cognitive health: IPA may influence the brain by crossing the blood-brain barrier and helping protect cells from oxidative stress, with emerging evidence of its role in maintaining cognitive function.
Liver & muscle support: In experimental studies, IPA has shown promise in supporting fat metabolism in the liver and contributing to muscle function.
Bone health: Recent studies suggest IPA contributes to bone strength by supporting balanced bone turnover and immune signaling.
Longevity & healthy aging: IPA is consistently associated with markers of resilience and vitality across organ systems, supporting longevity through its combined antioxidant, barrier-protective, and immune-balancing effects.

These associations do not imply diagnosis or treatment, but they highlight IPA as a meaningful marker of microbial function that can be shaped through diet and lifestyle - especially fiber intake.

Why include IPA in our Gut Health Test?

Measuring IPA offers a unique window into the activity of the gut microbiota – especially its ability to convert tryptophan into health-supportive compounds. By tracking IPA levels and related ratios (e.g., IPA/TRP, IPA/KYN), we gain insight into the balance between microbial metabolism and stress-related host metabolism.

This test is not meant to be diagnostic. Rather, it provides a snapshot of gut microbial function and how it may be supporting your metabolic and immune balance. Because IPA levels can respond to diet, and especially fiber and polyphenol intake, tracking its levels can help individuals see how dietary choices shape their internal environment over time.

Quick summary

IPA is made exclusively by gut microbes and supports gut integrity, immune balance, and metabolic resilience.
High IPA levels reflect a balanced, well-fed microbiome and greater systemic resilience.
IPA is a powerful indicator of how well your gut health is supporting whole body health.

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